INFLUENCE OF N-(4-ACETOXYBENZOYL)POTASSIUM GLYCINATE ON SENSOR-MOTOR AND COGNITIVE DISORDERS IN RATS WITH CHRONIC CEREBROVASCULAR INSUFFICIENCY

The effect of a new conjugate hydroxybenzoic acid with glycine on sensory-motor and cognitive impairments in experimental animals chronic cerebrovascular insufficiency (CCI) was studied. CCI modeled rats by stenosis thelumen the carotid arteries 60 %. 40 days after operation, groups were formed test compound administered for 14 days. Citicoline used as reference drug, saline placebo. After treatment Rotarod, Adhesion Test, Novel Object Recognition (NOR), Morris Water Maze tests, severity assessed. It noted that placebo treatment, pathology accompanied pronounced impairment coordination function forelimbs, wellas (impaired short-term long-term memory NOR maze tests). course introduction anew contributed to significant improvement functions CCI. neuroprotective comparable drug citicoline.